Aminoglycosides

<Medications>   <Med Classes>

<Index>

 

 

 

Features

-  Antibiotic

-  ..mycin/micin

-  Bactericidal sugar w amino group

-  Micin vs mycin = derivitave bacteria

-  Poor oral bioavailabilty

-  Requires serum blood levels to check for toxicity

 

Mechanism

-  Unknown, protein synthesis inhibition? (30S)

 

Uses

-  Serious G- infections

-  Most G- aerobic bacilli

-  Pseudomonas aeriginosa

-  Not active against anaerobes

 

Side Effects

-  Renal, vestibular & ototoxicity

 

Drugs

-  Gentamicin

-  Neomycin

-  Streptomycin

-  Tobramycin

-  Anthrayclines

-  Group of Aminoglycosides used in chemotherapy