Amoxycillin

<Medications>

<Index>

 

- Augmentin (Amoxycillin + Clavulanic Acid)

 

Definition

- Penicillin class of antibiotic

 

Features

-  Broad spectrum

-  Non-allergic rash may indicate EBV infection (80-90% pts w EBV)

 

Mechanism

- Bacteriocidal via disruption of bacterial cell wall synthesis (via PBPs)

 

Coverage

- Typically G+

 

Indications

-  

 

Dose

-  

-   

 

Precautions

- Anaphylaxis

- Diarrhoea, nausea

- Rash

 

Side Effects

-  

 

 

 

Augmentin

(Amoxycillin + Clavulanic Acid)

<Amoxycillin>

 

Features

- Augmentin (Amoxycillin + Clavulanic Acid)

- Addition of beta lactamase inhibitor for greater coverage

 

Coverage

- For G+ & G- cover

- More effective against beta lacatamase producing G+

- G-

-  Moraxella catarrhalis, Haemophilus influenzae, Proteus, E. Coli, Klebsiela

-  Some anaerobes

 

Indications

- Bites: human, dog, cat..

- Contaminated wounds

 

Dose

- Average duration 5 or 7-14 days

- Usually BD

- Augmentin Duo

-  Amoxycillin + Clavulanic acid 500/125mg PO BD

- Augmentin Duo Forte

-  Amoxycillin + Clavulanic acid 875/125mg PO BD

-  Paeds 22.5 + 3.2mg/kg PO BD