Blood Film

Last updated 03.11.12

 

Red Blood Cells (RBCs)

- Size: normally same size as lymphocyte nucleus

- Morphology

- Color

 

- Reticulocytes

-  Increased size compared to RBC --> increased haemolysis

 

- Target Cells (Codocyte): bullseye RBC with bright white center & dark ring

-  Cells lack iron

-  Liver disease (especially with obstructive jaundice), splenectomy, hypochromic aneamia (haemoglobinopathies, IDA)

 

Target Cells

 

Target Cells

 

- Burr Cells (Echinocyte): CRF, uraemia, liver disease

 

- Spurr Cells (Acanthocyte): liver disease, lipid disorders, haemangiosarcoma, DIC

 

- Sickle Cells (Drepanocyte): hereditary sickle cell disorder

 

- Anisopoikilocytosis:

- Poikilocytosis

-  Bite Cells: haemolytic anaemia

-  Spehrocytes

-  Tear Drop

 

- Inclusion Bodies:

-  Heinz Bodies: denatured Hb within RBC

-  Alpha thalassaemia

-  G6PD Deficiency + anti-oxidant drugs (ie: antimalarials)

-  Chronic liver disease

 

- Spherocytes: spherical shaped RBCs

-  Large: haemolytic anaemia

-  Small: severe burns

-  Variable: hereditary spherocytosis

 

Spherocytes

 

WBC

- Smudge Cells: Chronic Lymphoblastic Leukaemia (CLL)

 

  

 

 

References