Clostridium Difficile

(C. Diff)

<Bacteria>   <Micro-Organisms>

<Index>

 

 

Features

-  G+ class of bacteria

-  Spore forming bacillus

-  Obligate anaerobe

-  Common in environment esp soil

-  Faecol-oral transmission

-  Disinfectants w bleach are effective

-  Produces several known toxins

-  Produce the diarrhoea & inflammation

-  Enterotoxin (Toxin A)

-  Cytotoxin (Toxin B)

-  Binary Toxin: unclear role in disease

 

Presentation

-  Causes Pseudomembranous Colitis

 

Dx

-  Cytotoxic Assay

-  Toxin ELISA

-  Stool Culture