Creatinine Kinase

(CK)

<Pathology>

<Index>

 

Definition

-  Cardiac enzyme used as indicator of cardiac muscle damage

 

Features

-  Isoenzymes

-  CK – Muscle (CK-MM)

-  CK – Brain (CK-BB)

-  CK – Heart (CK-MB)

-  1-3% of skeletal muscle CK

-  Also located in uterus, prostate, GIT, diaphragm & tongue

 

Indication

-  Dx AMI, DDx angina

-  Rise 3-8 hrs post AMI 

-  Peak 24 hrs

-  Persist for 2-3 days

 

CK-MB

-  Normal with chest pain

-  Angina

-  Serial CK-MB

-  On presentation of chest pain

-  6hrs post, 12hrs post (0, 6, 12)

-  Elevation

-  AMI 

 

CK-MM

-  Elevated

-  Rhabodmyolysis