Chronic Lymphoblastic Leukaemia

(CLL)

<Presentations>

<Index>

 

Features

-  Dx often by incidental leukocytosis

-  Many clinical overlaps between lymphoma & CLL

 

Ix

-  Blood Film: smudge cells

 

Dx

-  Lymphadenopathy

-  Hepatosplenomegaly

 

Mx

- Elderly pt – late stage: watchful waiting

- Young pt + early disease: marrow transplant

- CHOP

-  Cyclophosphamide

-  (Hydroxyldaunorubicin) Doxorubicin

-  (Oncovin) Vincristine

-  Prednisone

- Rituximab (Mabthera): monoclonal Ab B cell