Chronic Myeloid Leukaemia

(CML)

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Features

-  Age: all, > 55++

-  Cytogenetics: 95% Philadelphia chromosome

-  Often incidental Dx

 

Associated S/S

-  Hepatosplenomegaly

 

Ix

-  FBE: leukocytosis, thrombocytosis

-  Blood Film

-  Bone Marrow: hypercellular

 

Mx

-  Hydroxyurea

-  Maintain cell count in chronic stage

-  No effect on progression

-  Marrow transplant

-  1st line therapy if < 50

-  60-75% cure if HLA matched (ie: sibling)

-  Interferon alpha + cytarabine

-  1st line therapy if > 50

-  30% remission

-  STI-571

-  Tyrosine kinase inhibitor

-  Newer agent, better results