Cefuroxime (Zinnat..)

Last updated 10.08.12

 

Definition

-  2nd generation cephalosporin class antibiotic

 

Features

-  Often used in patients with non-anaphylactic reactions to Penicillins

- Can cross blood brain barrier

- More broad spectrum than Cephalexin (1st generation)

 

Mechanism

-  Disrupts bacterial cell wall synthesis

 

Coverage

-  Haemophilus influenzae

- Moraxella catarrhalis

- Borrelia burgdorferi

- E.Coli

- Neisseria gonorrhoea

- Proteus mirabilis

- Klebsiella

- Lyme disease

- Strep: pyogenes, pneumoniae

 

Indications

- Sinusitis, otitis media

- Pneumonia: CAP

- Gonorrhoea

-  In place of Penicillin in hypersensitive patiens (excluding anaphylactic reactions)

 

Dose

-  PO only

-  Typically BD dosing

-  Adults: usual dose 250mg PO 12/24

-  Bronchitis/skin infections: 500mg 12/24 5-10days

 

Precautions

-  Interacts with Warfarin to increase INR

 

Side Effects

-  Pseudomembranous colitis

- May have cross sensitivity with Penicillins

 

  

 

 

References

 

NPS Medicinewise: Cefuroxime