Clomiphene

(Clomid)

<Medications>

<Index>

 

Definition

-  Medication used for Assisted Reproductive Technology (ART)

 

Mechanism

-  Selective Oestrogen Receptor Modulator (SERM)

-  Blocks central oestrogen receptors & prevent feedback effect

-  Causes rise in GnRH & FSH

-  Stimulate ovary to ovulate

 

Indication

-  Used in anovulatory infertility (PCOS..)

 

Dose

-  Initial dose 50mg oral (up to 250mg)

-  Days 2-6 of cycle

-  75% ovulate in 1st 3 cycles

-  If not consider other options

 

Side Effects

-  Hot flushes, abdominal discomfort, visual changes

-  Ovarian Hyperstimulation Syndrome (OHSS)

-  Multiple gestations