Drug Induced Vasculitis

(Allergic Vasculitis)

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Features

-  Leukocytocalstic small vessel (postcapillary venules) vasculitis

-  Penicillins, sulphonamides, thiazides

 

Dx

-  3+ of (71% sensitive, 84% specific)

-  Onset >16 yrs

-  Drug as above

-  Palpable purpura

-  Maculopapular rash

-  Skin biopsy: perivascular neutrophils