Hepatitis B Infection in Pregnancy

Last updated 03.11.12

 

Definition

-  Infection with or exposure to Hepatitis B virus during pregnancy

 

Features   

- Routine serology in antenatal screening

 

Causes

-  Hepatitis B virus

 

Associated S/S

-   

 

Complications

-  Infection in pregnancy does not increase maternal mortality or morbidity

-  Acute HBV infection increases risk of preterm labour

-  90% neonates born to HBsAg & HBeAg postive mothers become carriers wo immunisation & immunoglobulin

-   

 

Ix

-  Hep B serology

-  Part of routine antenatal screening

-  HBsAg positive: current infection

-  HBeAg positive: active replication = high risk of transmission

-  LFT

-  U&E

 

Mx

-  All neonates offered HBV immunisation at birth+

-  Should not be delayed >7 days

-  HBV Infected

-  Labour: avoid FBS, FSE

-  HBV immunisation to neonate

-  HBIG (Immunoglobulin) within 12hrs of birth

-  Breast feeding does not increase risk of transmission if neonate immunised & received HBIG

-  Post partum F/U for Hepatitis Mx

-  Notification to DHS (notifiable disease)

 

 

 

References

 

Hepatitis B in Pregnancy, King Edward Memorial Hospital, October 2008