Iron Studies

Last updated 03.11.12

 

Definition

-  Assessement of body iron stores and transport proteins

 

Indication

-  Used to Ix microcytic anaemia or in suspicion of Haemochromatosis or Iron overload

 

Procedure

-  Venepuncture: orange tube

 

Test

-  Serum Iron

-  Ferritin

-  Transferin

-  Transferin Saturation

-  TIBC

-  Soluble Transferin Receptor

 

Interpretation

-  Iron deficiency (IDA..)

-  Decreased

-  Ferretin

-  Serum Iron

-  Transferin Saturation

-  Increased

-  TIBC

-  Soluble Transferin Receptor

-  Iron overload (Haemochromatosis)

-  Decreased

-  Soluble Transferin Receptor

-  TIBC (or normal)

-  Increased

-  Serum Iron

-  Ferretin

-  Transferrin saturation

-  Inflammation

-  Decreased

-  Serum Iron

-  Transferin Saturation

-  TIBC

-  Increased

-  Ferretin

 

 

 

Serum Iron (Fe)

 

-  Varies meal to meal & diurnally (low in pm)

-  Best taken when fasted

-  Low specificity in presence of inflammation

-  N = 10-30 umol/L

-  Decrease

-  Iron deficiency (IDA..)

-  Inflammation (acute phase reactant)

-  Increase

-  Iron overload: liver disease (Haemochromatosis), thalassaemia

 

 

 

Ferritin

 

-  Stores iron there gauge of body stores

-  Most sensitive index of iron deficiency

-  < 30 = decrease

-  Iron deficiency (IDA..)

-  Normal

-  Iron deficiency (IDA..) + inflammation (equalizes)

-  > 300 = elevated

-  Inflammation (acute phase reactant), malignancy

-  Iron overload: liver disease (Haemochromatosis), thalassaemia

 

 

 

Transferin

 

-  N = 1.7-3.0 g/L

-  Increase

-  Iron deficiency

 

 

 

Transferin Saturation

 

-  Iron serum carrier protein

-  N = 0.15-0.45 (15-45%)

-  Decrease

-  Iron deficiency

-  Increase

-  Iron overload

 

 

 

Total Iron Binding Capacity (TIBC)

 

-  Another interpretation of transferin levels

-  N = 45-80 umol/L

-  Decrease

-  Inflammation (acute phase reactant), Iron overload

-  Increase

-  Iron deficiency

 

 

 

Soluble Transferin Receptor (STR)

 

-   Decrease

-  Iron overload

-  Increase

-  Iron deficiency