Features
- Ratio of combination used varies
- Reduced doses of both drugs required reduces side effects of each
- Apnoea less likely with reduced dose of Propofol
- Ketamine emergence phenomenon less likely with Propofol
- Some actions are opposing and counteractive
Dose
- IV only
- 1:1 = 1ml has Ketamine 5mg and Propofol 5mg
- In clinical practice both a single mixed syringe or dual syringes (with seperate drugs) are used
- Propofol 10mg/ml (standard solution strength)
- + Ketamine 10mg/ml
- Procedural Sedation
- 0.2-2.0 mg/kg of each of Ketamine and Propofol (0.4-4.0 ml/kg)
- Mean recovery time 15 minutes