Methotrexate (MTX)

Last updated 25.08.13

 

   

Definition

-  Antimetabolite drug

 

Features

-  Requires ongoing monitoring of FBE, LFT, U&E

-  Often coadministered with Folic acid

-  Teratogenic

 

Mechanism

-  Antimetabolite

-  Antifolate

 

Side Effects

-  Alopecia (not common with single dose)

-  Bone marrow suppression (not common with single dose)

-  Diarrhoea

-  Stomatitis

-  Gastritis

-  Photosensitivity

-  Deranged LFTs

-  Impaired renal function

-  Pulmonary fibrosis

 

Indications

-  Ectopic pregnancy

-  TOP

-  Autoimmune diseases

- RA, Psoriasis, Crohns disease

-  Cancer chemotherapy

 

Dose

-  IM, IV, S/C, intrathecal, PO

-  Ectopic pregnancy

-  Single IM dose

-  50mg/m2