Oxycodone

(Oxycontin, Endone, Oxynorm, Targin)

Last updated 26.09.12

 

Index

 

Definition

-  Opioid class of analgesic

 

Features

-  Part of analgesic ladder when Paracetamol & NSAIDs have been used

 

Indication

-  Moderate to severe pain from OA not responding to non-opiate analgesia

 

Types

-  Oxycodone SR (Oxycontin)

-  Slow release

-  Biphasic release: 40% of dose within 1st hr

-  Effect within 1hr

-  Overall effect for 12hrs

-  Oxycodone IR (Endone, Oxynorm)

-  Immediate release

-  Oxycodone (Proladone)

-  Suppositories

-  Targin (Oxycodone SR + Naloxone)

-  Slow release oxycodone + opioid antagonist

-  Reduces incidence of opioid related constipation

 

Doses

-  Oxycodone IR (Endone, Oxynorm)

-  (2.5) 5-10mg PO PRN dose 3-6/24

-  Oxycodone SR (Oxycontin)

-  5-20mg PO BD regular

-  Targin (Oxycodone SR + Naloxone)

-  Requires adjustment in hepatic disease

-  Reduce dose in renal impairment (ARF, CRF)

-  Morphine Comparison

-  Oral Oxycodone 1.5-2x as potent as oral Morphine