Proton Pump Inhibitors (PPIs)

Last updated 20.09.12

   

Mechanism

-  Binds H+/K+ATPase

-  Decreases gastric acid production

 

Features

-  More effective at lowering gastric acid than H2RA

-  One of most commonly prescribed drugs

-  Little difference between drugs in class

 

Medications

-  Pantoprazole (Somac)

-  Omeprazole (Losec)

-  Esomeprazole (Nexium)

-  Rabeprazole (Pariet)

 

Indications

-  PUD

-  Gastritis

-  GORD

-  Haematemesis

-  Screloroderma oesphagus

-  Prophylaxis against

-  NSAID induced PUD

-  Barrets Oesopahgus

-  Gastritis

 

Administration

-  IV or PO

-  Daily or infusion

 

Side Effects

-  Diarrhoea, stomach pain

-  Decreased acidity --> altered absorption of Digoxin, Ketoconazole

-  Flatus, bloating

-  Metallic taste in mouth, dry mouth

-  Fatigue

-  Sweating, headache

-  Peripheral oedema

-  Deranged LFTs

 

Contraindications

-  Cirrhosis

-  Severe kidney or liver failure (ARF, CRF, Chronic liver disease)