Pernicious Anaemia

Last updated 03.11.12

 

Index

 

Definition

- Autoimmune gastritis leading to B12 deficiency and megaloblastic anaemia

 

Features

- Thyrogastric cluster of AID

- 95% pts have Intrinsic factor Ab

- Age of onset 60yrs+

 

Associated S/S

- Serum B12 deficiency

- Megaloblastic anaemia

- Increased incidence of gastric Ca

 

Ix

- FBE

-  RBC, Hb: anaemia

-  MCV: microcytic, normocytic, macrocytic

-  MCHC: hypochromic, normochromic, hyperchromic

-  Platelets: thrombocytopaenia

- Blood film

-  Macrocytes = oval, anisopoikilocytosis

-  Hypersegmented neutrophils: >5 lobes to nucleus

 

Mx

-  

 

 

 

References